Coronavirus (COVID-19) Discussion Thread

[curl-6]

numberwang said:

curl-6 said:

Just a routine check; it's been resumed: https://www.abc.net.au/news/2020-09-13/astrazeneca-oxford-university-resume-coronavirus-vaccine-trial/12658984 

Your third link even states "all participants had neutralizing activity" and Phase I and II human trial results have shown that it produces a "strong immune response" and "no serious adverse health effects": https://www.ox.ac.uk/news/2020-07-20-new-study-reveals-oxford-coronavirus-vaccine-produces-strong-immune-response

You are repeating their own marketing spin, not a reliable source. I am referencing the actual clinical outcome data and it is terrible. A vaccine that doesn't reduce infections and viral load has no way to increase herd immunity. Taking Vitamin D would likely give better immunity.

The clinical outcome of this vaccine:

71% fatigue

68% headaches

60% systemic muscle ache

61 malaise

51% feverish

18% fever over 38°C

Injecting painkillers to hide these symptoms for a vaccine is unacceptable. We are not talking about a rare medication for a last ditch effort to save someone but a vaccine that is supposed to be given to healthy people.

Fatigue was reported in the ChAdOx1 nCoV-19 group by 340 (70%) participants without paracetamol and 40 (71%) with paracetamol and in the MenACWY group by 227 (48%) participants without paracetamol and 26 (46%) with paracetamol, whereas headaches were reported in the ChAdOx1 nCoV-19 group by 331 (68%) participants without paracetamol and 34 (61%) with paracetamol and in the MenACWY group by 195 (41%) participants without paracetamol and 21 (37%) participants with paracetamol.

Other systemic adverse reactions were common in the ChAdOx1 nCoV-19 group: muscle ache (294 [60%] participants without paracetamol and 27 [48%] with paracetamol), malaise (296 [61%] and 27 [48%]), chills (272 [56%] and 15 [27%]); and feeling feverish (250 [51%] and 20 [36%]). In the of ChAdOx1 nCoV-19 group, 87 (18%) participants without paracetamol and nine (16%) participants with paracetamol reported a temperature of at least 38°C, and eight (2%) patients without paracetamol had a temperature of at least 39°C. In comparison, two (<1%) of those receiving MenACWY reported a fever of at least 38°C, none of whom were receiving prophylactic paracetamol

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext#%20

You're cherrypicking, and none of those side effects are serious, it's all minor, effectively harmless stuff.

From the same clinical data:

"No serious adverse reactions to ChAdOx1 nCoV-19 occurred". 

"In conclusion, ChAdOx1 nCoV-19 was safe, tolerated, and immunogenic, while reactogenicity was reduced with paracetamol. A single dose elicited both humoral and cellular responses against SARS-CoV-2, with a booster immunisation augmenting neutralising antibody titres. The preliminary results of this first-in-human clinical trial supported clinical development progression into ongoing phase 2 and 3 trials".

Last edited by curl-6 - on 16 September 2020