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For me, it's gotta be Bioshock.
Both the first game and Infinite are among the best games ever made in my opinion with their amazing settings and atmosphere, great storytelling, and fantastic plasmid-powered combat. The second game, while not quite in the same league, is still excellent as well.

Mass Effect, Bayonetta, Vanquish and Dead Space get honourable mentions as they are also superb.

So many terrific new IPs came out of the 7th gen.