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Tough call for me but I'm just about going for DS (GBA a very close 2nd). Just loved what it offered, the innovation of the console and the way it was implemented in its games. It's totally commonplace now but having a touch screen in gaming for the first time opened so many possibilities - especially for franchises that were perfect to take on the go such as Professor Layton and Phoenix Wright, Warioware and many more.

It was also the first handheld to do both 2D and 3D (PSP didn't come out till months later) which gave it great variety. Many great franchises got solid outings on it such as Dragon Quest, Final Fantasy, Sonic, Castlevania, Advance Wars as well as the usual main Nintendo IPs. Sadly the Zelda games were weak on it but Mario was strong with a enhancements to SM64 and a first original 2D title in 14 years!