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For the X-Men, I'd suggest Shield supporting a special training facility after more and more metahumans appear in the world and some having serious trouble dealing with them. A fight between it's two figureheads (Xavier and Magneto, if you couldn't guess) and their respective supporters devolves into a deep rivalry and finally into a real conflict between the two factions

As for the Fantastic Four, Moviebob had an excellent proposal (The FF being a superpowered Nuclear Family of the 50's and 60's in concept, he's having them sent into space during the Gemini Programm, hit by the cosmic storm which changed them - but also catapulted them 50 years into the future, where they not only have to deal with some super threat (not Dr. Doom for once), but also very much with their outdated 50's views and values in our times)

No idea about Deadpool, but maybe he wold be fine in a Netflix-style TV series of his own.