I think the lore gave enough history and details to set up another game. It may not be something straight from Lovecraft but it can be a based on as a development on his original story.
If I were too do a story, I would have it set 200 years after where your character who is caught in this vicious cycle of death and rebirth is pursuing a quest to break the cycle through breaking the link between the two worlds. He needs to traverse the chalice dungeons and find a way to enter the dimension of the ancient ones to break the seal between worlds.







