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I think that in a few years, Nintendo's highest selling franchise, per release (and type of game), will go as follows:
1. Pokemon (main series)
2. Mario Kart
3. Splatoon
4. 2D Super Mario
5. Super Smash Bros.
6. Animal Crossing (main series)
7. 3D Super Mario
8. Tomodachi series
9. 3D Legend of Zelda
10. 2D Legend of Zelda
Honorable mentions: Fire Emblem, Luigi's Mansion (if they make it a recurring series), and Donkey Kong
*This is assuming that NX is a hybrid console/handheld system.