Eevee could. Like a Mega Man-esque title where you go through a level and at the end acquire a new Eevee-loution could be good to see.
Aside from that, Lucario could star in his own fighting game if you ask me. You know, like Bayonetta but less sexually provocative (or more I suppose for some people). Pokemon are great but they're mainly secondary characters, so you'd have to really construct a personality in order for something to work.







