the only issue is a handheld will never be as powerfull as a real consol.... because your limited by battery & playtime needing to a thing, along with weight and heat.
All these issues arnt real problems for a consol just sitting next to your tv.
So its going to be weak compaired to a ps4 or xbox one.
Thats the main drawback...
There are tons of upsides though if done right.