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I've only been playing the game for about 10 minutes (got pulled away by the phone) and I can already say two things about it:

  1. The voice that says Resident Evil 4 at the Wii Menu and titles screen is made of win.  It's so bad in a powerglove way.
  2. The controls are great, and I'm even playing this left handed.  It's a little awkward  the first few minutes but you have it down cold by the time you reach the first save point.