Honestly I think in terms of gameplay it has been awhile, might say Witcher for RPG genre. That is the original witcher.

In terms of story telling I would really say Last of Us. Only because I think gaming in general does a really poor job of cinematic story telling for serious tone. We are fine when it comes to a tone of adventure, action, and sometimes comedy.

Indie games are good at telling a serious story, it just isn't cinematic. (Like the guy above me, posted a perfect example of how indies can be good at doing a serious tone.)