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*Mario Kart is amazing.
*I don't know if you're into strategy and RPG, but imo Fire Emblem is the best game on Wii right now. It also has endless replayability.
*You can't go wrong with Okami Wii I guess.
*Zack & Wiki is superb, but probably not for everyone. If you like brainteasers this is awesome.
*RE4 is absolutely worth it despite you beat the GC version, the controls are awesome and it includes 2 Ada Wong missions.

Between Okami and Z&W: Do you have lots of enclosed hours in which you game, or do you play an hour per day or so. Z&W was ideal for me when I was really busy at work, because it's very level based, so you can beat a level and quit.
If you have 3 hours a day Okami might be a more epic experience.