Basically you just install the program, give it a BIOS file that corresponds to the region of your games, and you're pretty much ready to go. You might have to configure controls or some other minor settings too but I can't really think about anything major. Then you just pop in the disc and let the emulator handle it. Of course for convenience you might want to rip the disc to your HDD so you don't need the disc every time; I'm sure the emulator has a way of telling what disc image formats it supports (for example, through some sort of an 'Open File' dialog). Yup, I'm pretty sure you can run both DVD's and disc images through PCSX2.
I'd tell you more accurately but I haven't really been using PCSX2 too much as my PC hasn't been able to handle it quite well enough. It's a shame as I haven't been able to play my PS2 games in years due to me not owning a TV and my monitor not having a proper connection in it.
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