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I'm going to go with Skies of Arcadia, which is maybe cheating considering I've never actually played the Gamecube version, only the Dreamcast version. Then I would say Sonic Adventure 2...but I've barely played the GC version, mostly the DC version.

If I have to choose a game I've actually spent considerable time with on GC, I'd say SSBM. That's the GC game I've spent the most time on, and had the most fun with, even though I'm not very good at it.