Well, the three most successful have been Nathan Drake, Commander Shepard and Marcus Fenix.
But Marcus Fenix has the personality of a brick wall and even less likeability, and Shepard can't really be considered an influential character because he isn't a character at all. He is of indeterminate race and gender, and makes no decisions at all other than those you tell him to make.
That leaves Nathan Drake, who is a hugely popular, very charming and surprisingly deep character who can hopefully be fleshed out further in future games.