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If you are talking as a whole franchise then it doesn't really make sense to exclude handhelds. Nearly as many handhelds sold this past generation as home consoles. Part of Mario's value and power is that there are great iterations on both home and handheld consoles.

The numbers notwithstanding I would have to say Mario because it is still far more likely to still be popular 5 years from now.  Activision should be pretty happy with themselves though.