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I can't say for certain because I have like 25 mods lol.

there are a couple mods that might help this is a 4gb mod. That allows the exe to utilize 4gb instead of 2 gb of ram
http://newvegas.nexusmods.com/mods/35262

There's also a stutter remover that works well
http://newvegas.nexusmods.com/mods/34832

I've tweaked mine to high hell and it runs great. But I spent a lot of time changing textures, animations, skeletons, gameplay etc.

 

 

EDIT:

My guess is there's more crap so it runs worse. Obsidian's/Black Isle always been very buggy... what you get in gameplay/writing, you lose in competent programing.