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These are the games that will push large numbers of units of the Wii U, beyond NSMB U (which is likely the one selling the system right now) and Monster Hunter 3 in Japan. Note that they're not in a particular order, beyond "the order that I think of them"

- Zelda
- Smash Bros
- Pokemon
- Mario Kart
- 3D Mario
- Wii Sports sequel
- Dragon Quest X in Japan
- Wii Fit U

Metroid could have a huge impact, in theory, but it's not a big enough franchise at this point in time - it could, theoretically, become huge, but only if Nintendo tell Sakamoto to take a hike. I think that Nintendo's best bet would be to place it into the hands of either Retro or Platinum Games, or possibly Monolith Soft if they want a more Japanese flavour to boost the series there (Platinum is Japanese, but their games are more... mixed in style). It could actually become Nintendo's answer to Halo, in terms of franchise size. But as the situation stands (at least, to our knowledge), it's not going to be a big system-seller.

Zelda under Aonuma has struggled somewhat. It will still be a system-seller for Nintendo, but if they drop Aonuma's direction and make appropriate adjustments, the franchise could end up being bigger than 3D Mario currently is, with 10+ million sales.

Also noteworthy are Kingdom Hearts and Final Fantasy - if Nintendo can get one or both of these as an exclusive on the Wii U, they'll sell systems worldwide. But they need to get them, first - that Square Enix has Dragon Quest as an exclusive is encouraging.