Probably the world economy will die because the internet died after too many online connections.
Little more serious:
Kid Icarus
Pikmin
F-Zero
Pilotwings
Waverace
1080
Animal Crossing
Starwing/fox
Donkey Kong
After that:
Zelda
Mario
Metroid
Wow all are million sellers in the making! And that's not even mentioning 3rd party games.