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Just for fun as well here are some of the more notable multi-plat, non-family-centric titles on Nintendo platforms over the years ...

Call of Duty 3 (Wii) 2.16 million ww
Mortal Kombat II (SNES): 1.93 million ww
Call of Duty: World at War (Wii): 1.86 million ww
The World Is Not Enough (N64): 1.55 million ww
Mortal Kombat III (SNES): 1.53
Call of Duty: Modern Warfare Reflex (Wii): 1.46
Soul Calibur II * feat. Link (GCN): 1.2 million ww
FIFA 11 (Wii) 1.04 million ww
Mortal Kombat Trilogy (N64): 960k
Madden NFL '99 (N64) - 900k ww
Madden NFL '08 (Wii) - 860k ww
San Fransisco Rush (N64) - 780k ww
Resident Evil 2 (N64) - 560k ww
NBA Street Vol. 2 *feat Mario and co. (GCN) - 540k ww
TimeSplitters 2 (GCN) 440k ww

Mortal Kombat II is technically a 1994 title, but what the heck.