1. Waiting for SSBB. The website was the best possible way to hype up the game. It was my first time at a midnight launch as well.
2. Super Mario Galaxy- A masterpiece
3. Playing Fragile Dreams alone in my room at night. A hauntingly beautiful experience.
4. Hours upon hours of Wii Sports with friends at launch.
5. Donkey Kong Country Returns - The best 2D platformer I've played since Super Mario World. Incredible level design and great difficulty curve.
Probably a few other I'm forgetting...