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Top 20 USA developed games, excluding call of duty and madden which would have each taken up 5+ spots. Only games that came out 2006 or later. Excluded handheld sales this time, but not PC or PS2. Hopefully i didn't miss anything. Big games missing that would have made it if vgchartz could track pc digital sales. Diablo 3, Left 4 Dead, Left 4 Dead 2, Portal 2, Starcraft 2. Basically Valve and Blizzard get the shaft though they are among the most popular American devs.

Ranking Game Sales Platforms
1 Kinect Adventures! 16.8m 360
2 Guitar Hero III: Legends of Rock  16m Multi
3 Elder Scrolls V: Skyrim 12.6m 360,PS3,PC
4 Halo 3 11.5m 360
5 Red Dead Redemption 9.9m 360,PS3
6 Halo: Reach 9.1m 360
7 Fallout 3 7.5m 360,PS3,PC
8 Star Wars: The Force Unleashed 7.3m Multi
9 Elder Scrolls IV: Oblivion 6.6m 360,PS3,PC
10 Gears of War 2 6.5m 360
11 Fallout: New Vegas 6.3m 360,PS3,PC
12 Halo 3: ODST 6.1m 360
13 Gears of War 6.0m 360
14 Uncharted 2: Among Thieves 5.7m PS3
15 Gears of War 3 5.5m 360
16 Medal of Honor 5.36m PS3, X360
17 Forza Motersport 3 5m 360,PS3,PC
18 NBA 2k12 4.8m Multi
19 NBA 2k11 4.8m Multi
20 Borderlands 4.6m 360,PS3,PC