I think Wii U will do well over the holidays (even the GameCube did fairly well during holiday seasons), but like the 3DS will struggle in the non-holiday months (sans Japan).
Pachter is being harsh, but I wouldn't really be surprised if Nintendo's market shrinks to this during this gen:
Wii U: 45-50 million (down from approx 100 million Wii)
3DS: 80 million (down from 150 million DS)
Still a sizable market, but I think they're going to take hits as 3DS/Wii U will not be the same type of hit with casual gamers now that everyone is making casual games (the "new"/"trendy" factor behind it is shrinking).