Kantor on 21 February 2012
Ratchet & Clank: Up Your Arsenal - 6-7 times
Warcraft III - 4-5 times
Age of Mythology - 4-5 times
More recently, I've played through both Uncharted and Uncharted 2 thrice each, mostly for trophy purposes (though it wasn't really difficult with games as brilliant as those). On a side note, I have yet to finish Uncharted 3 even once.
EDIT: And any game I really like will have been played twice, but I rarely go above two playthroughs.
(Former) Lead Moderator and (Eternal) VGC Detective 
