Disney's Epic Mickey (if you're a Disney fan then it's a no-brainer. If not then it's still a great Action-Platformer)
Sonic Colors (The game that broke the Sonic Cycle. Give it a shot!)
Tatsunoko vs. Capcom (Despite not knowing the Tatsunoko crowd, they had some cool characters.)
Endless Ocean: Blue World (The sequel to the wonderful diving game. One of the most unique and relaxing games out there.)
No More Heroes/Desperate Struggle (The two excellent games from Suda51. Both are sure to make you a fan of Travis Touchdown.)
Silent Hill: Shattered Memories (A reimagining of the original Silent Hill, the game is unique, tense, and unforgettable.)
Muramasa: The Demon Blade (Another VanillaWare masterpiece. The art style is so incredible, and the gameplay is simple yet satisfying.)
Little King's Story (A very odd and quite wonderful RTS game. Pikmin-like... but also very much its own game. Quite hard to describe, but great!)
Okami (If you haven't played the PS2 version {I'm sure you have}, then you need to play this masterpiece).
Resident Evil 4: Wii Edition (I think this is the definitive version with it's IR controls.)
Even though they're 1st Party, don't miss out on...
Kirby's Epic Yarn (The graphics and music will make you smile, and the gameplay is very engaging!)
Donkey Kong Country Returns (Platforming brilliance by Retro Studios.)
Metroid Prime Trilogy (If you can get your hands on it... get your hands on it! The first two games are (imo) made even better by the IR controls).
Fire Emblem: Radiant Dawn (I love this series, and I think this is the best one. Try and get Path of Radiance on the GameCube too [it's the prequel])
Have fun Xen!
