Multiple disc games don't bother me at all. I just wish all games let me install them to hard drive without needing to use the disc. That way I'd be able to install the games and never risk damaging the discs shuffling them for each game. This goes for PS3, Xbox 360, and PC. I say the same for Wii, but it doesn't have a real hard drive.
I know, I know, the disc is needed to prove you own the game. Sure it's not going to happen, but that's what I want.