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Galaki said:

How does Rune Factory compare between the Wii and DS versions?

Frontier is the longest and hardest one by far. Its dungeons are all much bigger than their DS counterparts, enemies hit harder, healing is less effective, etc. On the flipside, the last two DS games generally have more emphasis on the town and character portions of the game, with far more features offered in that area. I prefer the Wii version, but I can see why others would like the DS ones better, since they are fairly different.