Mummelmann on 02 March 2011
I can't think of anything major save for a new console or something related to Vitality Sensor. Since I have no faith in the Vitality Sensor revitalizing (pardon the pun) the Wii on it's own and I don't think Nintendo do either, I'm going with a new console.
There is an off-chance that it could pertain to F-Zero or perhaps even Star Fox (which is the one major thing missing on a Nintendo console for me this gen).
