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1. The Last Story - If this doesn't come over, I would hurt someone. My favorite genre, by my favorite group of people, and add in the fact that this is a "nintendo" game.

2. Mass Effect 3 - The title and previous games justify this title alone, and this is the conclusion of the trilogy, well until Mass Effect Reach :P comes out. 

3. Witcher 2 - After watching the trailer were you have two possibilities, it makes looking forward to it, and for someone that can be completist, it might also piss me off. 

4. Final Fantasy Agito - I moved infamous 2 and Uncharted 3 down for this one but forgot to actually put it in! :p

5/6. Infamous 2/Uncharted 3 - Honestly speaking I can't decided, which one I want more, both look to be awesome sequel to awesome games. I think the current pattern would go something like this Uncharted 3 > Infamous 2 > Uncharted 2 > Infamous > Uncharted.

7. Dragon Age: Origins - Taking stuff out of Mass Effects book, and adding tactics....sign me up.

8. Legend of Zelda: Skyward Sword - My hyped meter has dropped for this due to lack of information for the past 6 months, nintendo give me something.

9. Pokemon White/Black

10. EVERYTHING ON THE 3DS!