Nintendo confirmed backwards compatibility last I heard.
definitely get the World Ends With You
all the castlevania games for the DS are great (portrait not so much)
Advance Wars games are good
Chrono Trigger if you haven't played it
Shin Megami Tensei: Devil's Survivor is great
Zelda: Phantom Hourglass & Spirit Tracks are good
Professor Layton I hear is brilliant
GTA Chinatown Wars can be fun
metroid prime hunters is good if you can find it and you like those games
Soul bubbles is a rather unique game
and if you like metal slug you could pick 7 up
the DS fire emblem remakes (of the japan only SNES ones) are worth a look to
committing to get all the good DS games could be very bad for your wallet BTW
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