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God of War 3 PS3 will out sale Mass Effect 2 xbox 360. I do not think there is any doubt about that.

However, Mass Effect 2 is a 360 and PC game. Bioware is one of the highest selling PC game makers out there. Dragon age sold more on PC than 360 / ps3 quite easily. Mass Effect is more likely to be more even in the split.

Edit: Unlike alot of other posters, I have played both. I prefer Mass Effect 2 but both are very good games.