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So firstly, I assume we are ignoring multiplatform games, because then no

If we are going to ignore that, then maybe. I don't expect any PS3 or 360 games to break the 15m mark, let alone the 18m mark to beat San Andreas, so the question is, can that many more Wii/DS games get above 18m, and I don't any more than just a few will.

Mario Kart DS and Wii Sports resort are very likely, and maybe NSMB Wii sometime next year, but beyond that, I am not sure if any new games are going to take over from Nintendo's current top selling games