I bought The Legend of Zelda: Twilight Princess without owning a Wii, but I couldn't find one in stock at the time.
Personally I would never buy anything but big first party Nintendo games before owning the system, as those don't drop in price while every other game does. For example with the OP, you want to buy Uncharted 2, but it is highly likely to drop to $30 with Sony's discount line and if you have to play through MGS4 and Uncharted first you never know how long it will take before you get around to it.








