You can definitely play ToS2 without playing ToS and without getting confused. But since ToS is supposedly a lot better than ToS2 it may not be the best idea.
There are voices in the skits in ToS2, and there are only a few annoying voices. Sadly one of these is the main character, but c'est la vie.
If you want a Wii game I suggest Little King's Story over ToS2, it isn't as long, but it is better.
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