Soundwave on 07 June 2009
Since the Wii "took" the NSMB sequel away, maybe the DS could get a new Donkey Kong 2D platformer in the vein of the DKC series. Donkey Kong World would be cool.
Nintendo has also brought back some franchises like Sin & Punishment and Punch-Out!! which I didn't think we'd ever see again honestly. I think F-Zero and Star Fox will happen.
Next Level Games (Punch-Out!!, Mario Strikers) actually would not be a bad studio to handle the next Star Fox IMO. EAD could oversee it.
