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Mr Khan said:

So long as they learn their lesson from CTYD about not shoehorning technology, i'd be willing to give it a shot.

Considering how RE5 is apparently just RE4's engine on steroids (kinda like Chris, really), I doubt shoehorning will be an issue.

Maybe they can just ditch the girl (and forced co-op) entirely, thus making the whole thing easier on the Wii.