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I love Platnium/Clover but I don't think they're going to have a ton of luck with Bayonetta (much like MadWorld). 

I would suspect 

Wii Sports Resort (3 million+)

Final Fantasy XIII (2.5 million)

Monster Hunter 3 (800k)

Wii Fit Plus (3 million+)

Final Fantasy Crystal Bearers (400-500k)

Pikmin 3 (600k)

Gran Turismo 5 (900k)

 

Would be my picks for games that can actually come out this year and have any real impact on hardware sales. A game that sells 300k LTD is not creating any type of real long term momentum for a platform. 

Everything else is gravy. 

Something like Mario & Sonic Winter Olympics is likely to outsell Bayonetta, Vesperia, etc. easily.