Just one, eh? In that case, I think you should make it...damn, this is hard. If you haven't played it before, Resident Evil 4 deserves a play-through, although the reasons are too many to list.
If you've already played that, then go for World of Goo (WiiWare). It's a very well-designed physics puzzle game that's fairly lenghty, pretty ingenious, and challenging without being frustrating.







