My last name is Nesser.
In grade school, I somehow always ended up having the highest grades despite being a notorious day-dreamer. In scholastics placement, I was 99th percentile in everything except reading comprehension (lol).
Being that this was grade school 1st through 8th grades, kids would always come up with nicknames for classmates using rhyme.
My nickname became Prof, after I was referred to as Professor Nesser. After some time, this was shortened to Prof.
Later on, while AIM was becoming more of a thing, I had to make a new username that would stick out to my friends, I tried theProf but it was taken, so I just added the two zeros because it was the year 2000.
My newest nickname that I go by on most websites is "scrambles" or "scrambles00" which is from the Metalocalypse episode in which Nathan Explosion names a killer hurricane 'scrambles the death dealer'.