Notice: If I missed any characters just state them. They must be new IP's.

although i only care for 1 character on here (Lightning) i would say Ezio is the more than obvious choice

Sackboy?

Hmm, Ezio is an obvious choice but I really like John Shepard too.... Then there's John Marston...

A lot of the list like Fenix and Drake aren't original enough to be considered IMO.

None of the above.

If we're talking most influential in terms of character design and leaves behind footprints for future games, then hands down Glados.

Well 4 of the characters mentioned above is not even a new IP for starters.

Influential character? None. Characters all have different personalities. Games would be different.

best characters, maybe GlaDos or Wheatley from portal. Maybe even Shephard.

Fenix and Drake arent original enough to be considered? What the..... LOL. Fenix is a gritty, no nonsense military dude, Nathan Drake is a historian/thief who has a comical sense of humor.

Influential? None of them but I like Lightning and most Final Fantasy characters.

Which four characters?

Eh. Lightening is the most interesting, but I don't know that any of them are all that influential.

I vote Claptrap.

GTA4
Red Dead
Batman 
FFXIII

All these are not new IP games.  New Characters but not new Ip's.  If you are just talking about new characters then change the title to best new characters of the generation.