im, assuming u mean sales?

wii-some casual game with the word wii in front of it.

360-reach

ps3-gran turismo 5

pc-starcraft/cataclysm

ds-pokemon

psp-iuno kh:bbs mostly casue of japan?

Shit, i did forget about Peace Walker.

Yeah, i'll change my PSP entry to that...

Wii Metorid Other M

PS3 God of War 3 or Final Fantasy XIII

360 Halo Reach

PS3-GT 5 (looks great)
360-Halo Reach
Wii-Id say Zelda BUT........as we found out at last E3 they might have something else in the pipeline that might blow our socks off

Quality wise

Wii: Zelda Wii (I hope the real name is way better than this). I hope for once they make the blade to be a bit more realistic. I don't need to see amputations or anything, but one hit or two should always be enough (Star Wars: The Force Unleashed was a letdown in that aspect). I hope they use Motion Plus to make battles more tactical. That would be great.
Mario Galaxy 2 will sell better and Metroid: Other M will be as good as Zelda, I hope, but no Motion Plus compatible and therefore less innovative.

PS3: I think it should be around Heavy Rain / The Last Guardian / FF Versus XIII (if it is realesed in 2010).

I don't own an XBOX 360 and I don't know much about its 2010 line up, but I know for sure that I would love to ever play Alan Wake.

Wii: Zelda

PS3: God of War 3

360: Fable 3

DS: Golden Sun

PSP: KH:BBS

Playstation 3: Gran Turismo 5

Xbox 360: Halo: Reach

Nintendo Wii: Zelda Wii or Super Mario Galaxy 2.

Nintendo DS: Pokemon HeartGold and SoulSilver.

Playstation Portable: Kingdom Hearts: Birth By Sleep.