@ Natedog4000: Project Hammer was planned as a new IP. Hope they resurrect it. Sadness looks promising too even we haven't seen any gameplay elements yet.
I expect they will make more original games and and a dozen of spin off from the Mario universe like a new Luigi adventure, a new Wario platformer, Yoshi, Donkey Kong...
And possible offerings in the coming years could be a true Pokemon game and not a spin off, Animal Crossing with 24 connect, A Nintendogs Wii, Kirby, Kid Icarus, Wii Sports 2, F-Zero, new balance board games...
Another Wii Zelda is a certainty. I'm pretty confident Miyamoto has a few new tricks up his sleeves as well. Retro studios will be working on something new too. Monolith Studios will work on a new RPG...
The future looks bright, I'm not sad at all, to the contrary I'm excited to what the next Nintendo game will be. And in the meanwhile a lot of 3rd party support will shift from PS3 & Xbox360 to Wii to fill in the blanks.