"That's TREASURE HUNTER" - Locke Cole FFVI

I know where "You Spoony Bard!" is from ;)

Magus (Chrono Trigger):  Sigh... To have gained so much, and then have lost it again...
 
Magus (Chrono Trigger):  Except for you and I, this world is populated by cretins...
 
Magus (Chrono Trigger):  If history is to change, let it change!  If the world is to be destroyed, so be it!  If my fate is to be destroyed... I must simply laugh!!
 
Magus (Chrono Trigger):  Idiots... Nothing can live forever.
 
Cats (Zero Wing):  All your base are belong to us.
 
HK-47 (Knights of the Old Republic):  Translation: 98% probability that members of the miniature organic's tribe are being held by Sand People, master. Doubtless he wishes assistance. [There is also a] 2% probability that the miniature organic is simply looking for trouble and needs to be blasted. That may be wishful thinking on my part, master.
 
HK-47 (Knights of the Old Republic):  Definition: 'Love' is making a shot to the knees of a target 120 kilometers away using an Aratech sniper rifle with a tri-light scope. Statement: This definition, I am told, is subject to interpretation. Obviously, love is a matter of odds. Not many meatbags could make such a shot, and fewer would derive love from it. Yet for me, love is knowing your target, putting them in your targeting reticle, and together, achieving a singular purpose, against statistically long odds.
 
Minsc (Baldur's Gate): Fool me once, shame on you; fool me twice, watch it! I'm huge!
 
Minsc (Baldur's Gate): Swords! Not words!
 
Minsc (Baldur's Gate): Evil 'round every corner...careful not to step in any.
 
Minsc (Baldur's Gate): There is strength in numbers, and I am two or three, at least.
 
Minsc (Baldur's Gate): Butt kicking for goodness!
 
Minsc (Baldur's Gate): Boo points, I punch - it's a very simple relationship, but it is effective!
 
Minsc (Baldur's Gate): Evil, meet my sword! SWORD, MEET EVIL!  
 
Edwin (Baldur's Gate): Elminster this, Elminster that. Give *me* 2000 years and a pointy hat and I will kick his arse.  
 
Jaheira (Baldur's Gate): You are amusing ... in a what the hell is wrong with you kind of way.  
 
Minsc (Baldur's Gate 2): I trust those who prey on children no farther than they can be thrown, even if I manage to throw them pretty far!  
 
Minsc (Baldur's Gate 2): Minsc will be free! These bonds will not hold my wrath! Butts will be liberally kicked in good measure!  
 
Minsc (Baldur's Gate 2): What? Boo is outraged! See his fury! It's small, so look close. Trust me, it's there.  
 
Viconia (Baldur's Gate 2): He dropped to his knees to beg for mercy, which offered me height advantage as I smashed in his skull with a sledgehammer.  
 
Lilarcor (Baldur's Gate 2): I'm sharp, I can come up with something... OK... find someone who knows what you want to know and threaten to kill them! Yeah! Then kill them! Woo-hoo!  
 
Mazzy (Baldur's Gate 2): Honestly, Yoshimo, I am sick and tired of humans and large folk calling me cute!
Yoshimo (Baldur's Gate 2): I cannot help it! You are like a miniature prophet of doom.
Mazzy (Baldur's Gate 2): Oh, shut up! I won't seem so cute if I break your legs.

 
There's more, but the Baldur's Gate series wins for best quotes in video game history.

"Do A Barrel Roll!!" - Peppy Hare Star Fox 64

  "Hey!" - _^Navi

'But for now...This is were i take off. - ending guy HL 2.

"I feel asleep" Metal Gear NES
"Yo gangsta! Get ready to gang bang!" Bust-a-groove
"Jill, why don't you, the master of unlocking, take this lock pick." Resident Evil
"I am Error." Zelda II

StarFox 64 Never give up, trust your instincts! +1 for cheesiness

Parasite eve - somewhere late in the game Aya said the cheesiest line in the VG history. I do not remember it exactly, it was something like: I can feel Maya mithocondria, Maya lives inside me. My mithocondria and Aya mithocondria are the same.

Killzone - What the fuck is a Shakespeare? This may reflect the culture level of those who play games like that.

Dragon Quest 8 - Cor Blimey!

LSL MCL - the whole Lesbian Nights song

Zelda MM - I do not remember the sentence, but the part where the mask salesman teaches you a song and ask if you got the mask. When you say no, he makes the most evil face in all Zelda history. It scares me even in the present day.

"LISTEN!" - Navi Ocarina of time

"War, war never changes" - Fallout