I haven't seen any mission glitches. I've just finished first play though and although I saw graphical/AI glitches - none of them were terrible and most were amusing - I didn't have a problem with any missions.
BTW Starcraft - the echo missions can be tricky in that you seem to need to wait for the echo to 'reset' sometimes between using your radar. I find the best bet is follow it until you hit combat or it disappears, wait until you are sure the echo isn't anywhere visible and trigger your radar again.
I thought a few times it had disappeared completely on me - but it hadn't, it was just playing hard to get. Triggering your radar too much seems to cause this to happen, so I only trigger once for an echo and never trigger again until I'm sure I've completely lost the echo.
p.s. my favorite glitch to far is with A.I. - I was fighting a bunch of reapers on the rooftops, and one with a shield was so keen to get to the edge to shoot me he pushed off all his buddies in the process! I love those kinds of glitches - they almost seem more real in a way because the A.I.s abruptly surprised you.
Try to be reasonable... its easier than you think...








