That room is the hardest in the game. Use the Rocket Launcher because all you really need is the pistol for the skinny guys and the Rockets for the fat guys. 

Weapon cheats are disabled in Crushing so are any game affecting effects, I found the room with the grenade launcher but the enemies Encroach me before I can get going. I can get the first 3 but the following 3 and 3 combo always gets me.

Also the enemies don't spawn until your feet touch the ground (hence the reason why Nate says, "Where did these guys come from?"

Huh...O.o Backtracking Glitch saves the day went all the way back to where I found the backpack and the enemies spawned making it easier to pick them out, it got a bit confusing though when the two shotgun folks spawned right behind and froze because things weren't how they were meant to be so I had to drop down but I still managed to do it :D Thanks for the tips :D

I beat it on Crushing and I did not find it that hard.

It just takes a lot of patience and you will catch the enemies off guard to kill them.

I guess, though every chapter seems to be a hurdle :( chapter 6 which wasn't difficult in Hard mode is now proving a chore :(

I beat it on crushing. I think it was chapter 4 that i had trouble and the last part with the church. other than that it is not to bad.

Well I look forward to doing it quite soon, should be a good challenge, though in hard I only died about 5 times from being shot because of weapon select {this will be playthrough number 4}

Since weapon select won't be available in Crushing I suggest you play through Hard mode without it first to get the hang of not having any ammo...because it happens a lot in Crushing :D

oouuuu yeah!!! Uncharted=Charted, I've just finished Crushing!!! Chapter 22 was easier than I thought (God bless Backtracking!! Makes chapter 22 a walkover), now on to the remaining treasures and I can finally get my 2nd Platinum.