MINOR ACHIEVEMENT SPOILERS: Nothing that should ruin the game for you.
JPL78: Even grazing someone's horse or bumping into them seems to make them go 'wild west' on you. The honor (sp) won't be a problem long term. I got the full honor and fame achievement then worked up a $5k bounty for the pardon achievement and still had full honor again before deleting and starting from scratch.
The gs for the pistol and rifle achievements (shotty isn't a separate cat, duh) and the secret ones for completing campaign missions will start adding up as you progress. Fort Mercer and El Precidio are 40 or 50 but there are 240 pts. tied up in 3 late story missions.
Plug away at the 100 gs for sp completion with Challenge and Stranger missions and use the 'Track' button in the Outfits menu or it will feel like a lot of work later. Other than that it's nickel and dime stuff. Not hard but time consuming. Easier when you're buffed. Break three horses, all gang hideouts in 24 hrs etc. can't be done till late game anyway.
The gold medal for combat was harder than I thought. You can replay in stats/missions once for speed, then accuracy and again for headshots rather than trying to be perfect. I still don't have the mounted weapon ach. Retried the three missions that should have added to my total a dozen times but no paso nada muchacho.
I'll leave online for someone who knows but a few sites have said you would need 500 mounted weapon kills in mp alone as they are considered as a separate category? Odd.