From IGN:
PSP Getting New Monster Hunter
Keiji Inafune wants to make series bigger than Dragon Quest.
February 25, 2009 - Monster Hunter Portable 2nd G was Japan's best selling game last year. In fact, the top three PSP games of all time in Japan all have the words Monster Hunter in their titles.
So it probably shouldn't come as a surprise to learn that Capcom is doing another Monster Hunter game for the system.
Capcom's Keiji Inafune made things somewhat official in an interview featured in the latest issue of Famitsu. Without getting into specifics, he said that Capcom is setting its sights on the next PSP entry in the series.
He did admit that he's not sure if it will be called "3rd," and that he expects it to be a ways off. But it appears PSP owners in Japan can look forward to more from the series.
Of course, we're still waiting for 2nd G to come our way as Monster Hunter Freedom Unite, so all this talk of sequels is a bit pointless.
http://psp.ign.com/articles/957/957033p1.html