FFIX - Vivi - "Sorrow. How do you prove that you exist...? Maybe we don't exist..."

"Congratulations you´re a pokemon master"

Also, how could have I forgotten this:

(After you beat LeChuck)
Guybrush: “At least I’ve learnt something from all of this.”
Elaine: “What’s that?”
Guybrush: “Never pay more than 20 bucks for a game.”

-The Secret of Monkey Island

"Some people just need killin" -Solid Snake, MGS

All Duke talk from Duke nukem 3D

"Your face, your ass, Whats the diffrence?"
"Its time to kick ass and chew bubblegum, And i'm all outta gum"
"Get back to work you slacker"
"mmmm, my kind of party"
"Shake it baby"

ect ect ect

Anything from Soul Caliber 2

And my least favourite
"Get me out of this hell hole" (in a damn annoying sing song voice)

This, and almost anything else GLaDOS says in the last level, pure win.

"Quiz time! What does D stand for? Destroyer? Daemon? My cup size?" ~ Excellen Browning of SRW:OG

Kotor/Kotor2
Revan: Can you help me out here HK?
HK-47: I'm 98% percent sure this miniature organic meatbag wants you to help find his fellow miniature organic meatbags.
Revan: And the other 2 percent?
HK-47: The other 2 percent is that he is just looking for trouble and needs to be blasted, but that might be wishful thinking from my part.

Revan: I survive. Somehow.
HK-47: Commentary: As do I. It is our lot in life, I suppose, master. Shall we find something to kill to cheer ourselves up? 

HK-47: Can I break his neck now master? It's been a long time fantasy of mine...
Revan: Maybe later...
HK-47: Did you hear that meatbag? "I'LL BE BACK!"
Yuka Laka: Err, well... ah...

Colonel Tobin: Will you just die already?
Atton: You know, just once, I wish someone was glad to see us.

Atton: "Anybody here catch that? All I understood was 'very.'"
Bao Dur: "I think he wanted us to give up the General to his poorly-trained group of assassins."
Atton: "Ah, well that would explain it. Which one do you want?"
Bao Dur: "I'll take the stupid one, who decided to threaten us rather than shoot us when he had the chance."

Jolee : I did it all for the Wookiees.
PC: The Wookiees?
Jolee: The Wookiees.

HK-47: Translation: He requires proof of good faith. We must make a contribution to his people that shows we are not a threat. Shall I blast him now, master?

Super Mario 64
"It's a me, Mario!"
"Let's a go!"

Super Mario RPG
"Are you...leaking?" -Booster, to a crying Princess Toadstool
"Booster, sir! There's a 70% chance that the object you're standing on is a cake..." -Snifit

Lufia 2
Dekar: "My love is my sword"
Guy: "If I were you I'd stay away from thoughts like that."

Earthbound
"Last night there was a solitaire tournament...I lost my shirt..." -Guy in Monotoli Tower
"I can sense...that...you have a controller...in your...hands..." -Sign in Moonside
"So, I'm having the machine delivered to you via Escargo Express. It's coming, 'Neglected Class.'" -Apple Kid
"Say, 'fuzzy pickles!'" -Photographer
"As strange as this may sound, there are statues of rabbits blocking your way." -After investigating rabbit statues in Dalaam
"I'll hate bathrooms for the rest of my life." -Venus Fan

Mortal Kombat
"FIGHT!"
"FINISH HER!"
"FINISH HIM!"
"FATALITY!"

Street Fighter
Hadouken!
Shoryuken!
Spinning Bird Kick!

ClayFighter
"Claytality."

The best ever: "YOU FAIL"

and

Anything from Star Fox 64...

"Andross' enemy, is MY enemy!"
"Hey, Einstein, I'm on your side!"
"Incoming enemy from the rear, drop altitude!"
"Peppy, long time no see!"

"My fist is the divine breath."
"Blossom, oh fallen seed, and draw upon thy hidden powers!"
"Grant unto thee the great power of the glorious mother of destruction!"
-Graft, the seeker of power.- Xenogear