Well to spawn the nukes you have to kill those green mines that count down. Once you kill the the last one and it blows up a small series of mines you can head to the other side of the planet to start on the next one. First nuke takes one green mine countdown, second takes two, thrid and up all take three each, or so I'm told. Enemies can kill them too, but it still counts. Basically concentrate on those. Grab bombs and upgrades when they're not much trouble, but otherwise just keep hunting for more mines and Nukes. The nukes can actually be easy to miss, despite their size, so stay alert and switch up your travel patterns. Anytime you see one bee line right for it. If there's a lot of crap in the way just bomb it for faster results.
Aside from that I've just got general advice. Maxed out gold melter can make a good force field if you're constantly swinging it around in a cricle, good for keeping away small debris. Endless mode is very generous with bombs, anytime you're near a bomb ship and there's too much going on to just shoot it, bomb it instead and get a net gain of one bomb. Boost if you feel desperate, and bomb coming out if you wind up somewhere worse.
Most people say just save the nukes for the 7 minute without dying thing. Honestly I found it easier just to hunt them down and keep blowing them up as quickly I could. Maybe that was just a lucky run, but that's how I did.