All your base are belong to us

"I caught a bass! if I catch a drummer maybe I'l form a band!" the animal crossing puns were soo bad they were great!

"Dogs of the AMS, time they made a move" (House of the Dead 2)

"Don't open that door !" (Resident Evil)

"How appropriate, you fight like a cow." (The Secret of Monkey Island)

"Look behind you, a three-headed monkey!" (The Secret of Monkey Island)

"You know what they say: 'To save the world, you have to push a few old ladies down the stairs.' " (Day of Tentacle)

"Up Right Left Down Chu Chu Chu" (Space Channel 5)

"Rise from your grave !" (Altered Beast)

"Welcome to your doom !" (Altered Beast)

"A defender of justice's favourite colour is red. Blue and black are always sidekicks, and don't get me started on white."

"She is no longer Anna, she has transformed into Super Anna."

"Jebus"

(Flay, Mana Khemia)

Edit: Points to Sig

Yea agree Duke Nukem had the best quotes :)

"It's time to kick ass and chew bubble gum. And I'm all out of gum."

"I'll rip your head off and shit down your neck!"

"Nukem 'till they glow, then shoot 'em in the dark!"

lol i forgot that!

"You are not ready yet"

"Our words are backed by NUCLEAR WEAPONS" - Civilization 2

there's another one in portuguese but I dunno how it's said in english :P

and of course, every Star Fox line:

"SO THIS IS ZONESS?"