Nope, never played Eternal Darkness.

#43: Whatever this game is, I want it. :)

#43 - A base-building game where your handful of people must survive the end of the world, as hell has taken over.

1. First you just need to survive, but after a while your group of survivors will do things like farming, crafting, both scientific and occult research, build shrines for rituals and an alchemic table complete with a philosopher's stone.
2. Research needs sometimes some specific items that you can scavenge, as in scientific books, research kits, scientific data to progress in that tech tree.
3. The more survivors you rescued and the more buildings you constructed, the more the forces of hell are aware of you and will attack your base more often.
4. Each survivor belongs to a class, but they will also have some additional talents that can influence a survivor in different ways.
5. Last hint for this game: All the maps and survivors are procedurally generated

#42 - A very long turn-based Fantasy game with clear influences at Civilization, Master of Magic and Heroes of Might & Magic.

1. The game world consists of a planet that has been blown to bits to avoid the forces of chaos to take it over, and the main story consists of assembling those shards and combining them with yours to recreate the planet.
2. This game has been made twice, once in 2D and then immediately they recreated it in 3D, although to this day with piss-poor performance.
3. Battles are turn-based in a manner similar to Heroes of Might & Magic, but every unit is singular instead of a group of troops and the hero is actively fighting along with them. Also, how many units one can bring along depends on the hero's command skill, and how high this can go depends on his class.
4. In the campaign, you fight for shards of the planet that once was and got broken up into many little maps. Each fight over one of those shards, no matter how many turns it took to conquer it (or get defeated and booted from it), counts as one turn in the grand scheme of things, and depending of the difficulty level chosen you'll have up to over 50 of those "turns" which each can take as long as an entire Civ playthrough.

Let's give it additional hints before revealing and go to the next batch so I can catch up:

#44: Hack isn't enough anymore, you need to slash.
Still as text, except with a tileset mod.

#43: Adorable dating sim... where one of the character really, really wants to date you. Doki Doki Literature Club as guessed by haxxiy.

#42: The grandmother of colony sims got a fresh layer of paint with this. Dwarf Fortress (Steam version) as guessed by UnderwaterFunktown.
We need our mushroom beer!

#41: Kittens will take over the universe!
From humble beginnings in the catnip forest to space travelling and time manipulation.

#40: You really need help sometimes. (not: It takes Two)
This is cozy multiplayer.

#39: Each year a new task for you to solve, while the machines take over the world.

#38: Lovecraftian horrors await you in this mansion.

#37: Collect coins to build defenses and attackers - but in the 80s.

#36: Pen&Paper Roleplaying game turns board game turns video game.

#35: Go on an epic quest, visit the Sorcerer's Lair, while encountering the Paranormal and meet a Shaman and draw Excalibur.